AEB Volume 16, Number 6: June, 2022

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Overview of Heat Shock Proteins (HSPs) in Prokaryotes

Nasser Aljohani, Jonathan Fletcher, Hatem El Shafey, Samah Ghanem, Saleh A. Kabli, Mohamed Morsi, Rami Aljohani

Abstract: Cellular defense mechanisms are the most primitive expression of a family of polypeptides called heat shocks or stress proteins (HSPs). Some of these HSPs are present in unstressed cells and play an essential role in polypeptide piling and translocation through membranes. Thus, (MC) were named. A variety of stresses, including hyperthermia, oxygen radicals, heavy metals, ethanol, and amino acid analogs, are expressed in HSPs. In clinically essential cases, including ischemia/reperfusion and circulatory and hemorrhagic shocks, the reaction to the heat shock is induced. All the above stresses have in common that they disrupt the tertiary protein structure and adversely affect the metabolism of the cells. Pre-handling of cells with moderate tension, enough to induce his expression, offers protection against subsequent insults. It is a "stress tolerance" coined phenomenon caused by the resolubilization of proteins denatured during stress. Furthermore, the second stress in stress-tolerant cells and species stabilizes or repairs the cellular structures (microfilaments and centrosomes) and processes (transcription, splicing, and translation). There is a large body of evidence to demonstrate that. Much research indicates that HSPs play an immediate role in stabilizing these incidents. As a natural mechanism for organ defense in dangerous environments and operations and in the fight against pathogens, HSPs have the inherent capacity to defend cells. This “stress tolerance” refers to the resolubilization of proteins that were denatured during stress. Besides, these are strengthened during stressful times and are resilient organisms. There is significant research saying that hypertension is involved in major cardiovascular diseases. HSPs can potentially enhance human recovery and combat pathogen infection.

[ Full Text Pdf 1-11 ] DOI: 10.22587/aeb.2022.16.6.1

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